2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

Retrospectively, medical records of dogs that had a diagnosis of a pheochromocytoma and treatment with Palladia were reviewed for information regarding response to Palladia, observed side effects, and overall outcome. Five dogs were identified that fit the inclusion cri- It is incurable once infiltrated into bone and lung metastasis, and the traditional therapeutic approach is less effective. Tumor cells rely on glycolysis, rather than mitochondrial oxidative phosphorylation, for energy production even under oxygen-rich conditions, which is termed as "Warburg effect". Since Warburg effect is characteristic for tumor cells, glucose metabolism is considered to be a therapeutic target in this regard. In this study, we investigated the contribution of glucose transporters on the cell growth of canine melanoma.