Title: 2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018 Document date: 2018_10_25
ID: 60ceejq1_436
Snippet: Median serum CCL2 was significantly higher in dogs with active necroinflammation (444 pg/mL; range, 144 to 896 pg/mL) compared to dogs without detectable necroinflammation (326 pg/mL; range, 59 to 1692 pg/mL; P = 0.008), but with considerable overlap between groups. Neither serum CRP nor AST:ALT ratios were significantly different based on fibrosis or necroinflammatory scores. Descriptive statistics were used to analyze categorical variables (age.....
Document: Median serum CCL2 was significantly higher in dogs with active necroinflammation (444 pg/mL; range, 144 to 896 pg/mL) compared to dogs without detectable necroinflammation (326 pg/mL; range, 59 to 1692 pg/mL; P = 0.008), but with considerable overlap between groups. Neither serum CRP nor AST:ALT ratios were significantly different based on fibrosis or necroinflammatory scores. Descriptive statistics were used to analyze categorical variables (age, gender, breed, side effects to Cys) and continuous variables (Cys dose, time to remission, ALT concentration). Means, medians, ranges, and standard deviations were calculated for continuous data. Wilcoxon, Student t-test, Fisher';s exact test, or survival analysis was used to evaluate the impact of prognostic factors (pre-treatment clinical scores, hypoalbuminemia, hyperbilirubinemia, ascites, fibrosis on histopathology, prolonged PT/aPTT) on remission.
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