2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

Prevalence of histologically confirmed HCC was 0.89% (41/4,607 cases). Dogs diagnosed with HCC was significantly older (median 11 years; range 9-15 years; P < 0.001) than reference population (median 9 years; range 0-20 years). Welsh Corgis were significantly predisposed to HCC (odd ratio [OR]: 4.13; 95% CI: 1.81-9.41; P = 0.0032). Breed-and age matched case control analysis revealed that thrombocytosis (27/40 cases; 67.5%), increased ALT (38/41 cases; 92.7%), increased ALP (39/41 cases; 95.1%), and hypercalcemia (12/32 cases; 37.5%) were significantly associated with HCC. In addition, 27 out of 41 dogs with HCC had at least one concurrent disorder. The most common concurrent disorder was hyperadrenocorticism (12 dogs), and the odds of hyperadrenocorticism in dogs with HCC were 3.36 times that of controls (95% Cl: 1.28-8.81; P = 0.020).