2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

Timing of conducting blood gas sample examination was pre: before initiating CPB, partial: after starting CPB, total: after aortic cross-clamping, rebeat: after aortic declamping, post: after completing CPB. In conclusion, toceranib elicited weaker reversal properties on pulmonary arterial remodeling and RVH, and therefore, a low dose of toceranib in comparison with sorafenib may not be a promising therapeutic agent for cardiopulmonary remodeling and PAH. Obesity is the most common nutritional disease in cats and is increasing in prevalence. Excess body fat predisposes the animal to deleterious effects on heart function and systolic blood pressure (SBP) alterations, arrhythmias and radiographic and echocardiographic changes have been described. However, there is not much information regarding the effects of obesity on the cardiovascular system of cats. This study aims to evaluate these effects on cardiovascular system of domestic cats and compare them with cats with normal body conditions. Thirty-six cats were allocated in two groups (20 obese cats and 20 cats with normal body condition) and submitted to SBP measurement; electrocardiogram (ECG); and chest radiograph to evaluate the cardiac silhouette by vertebral heart size (VHS). The echocardiographic measurements were evaluated, establishing a relationship between the data obtained and Body Weight, Body Condition Score (BCS) and Body Mass Index (BMI). SBP and VHS were statistically higher in obese animals in contrast to normal cats. In obese cats, the mean SBP was 148.5 ± 29. 6 Weight. A quadratic relationship was also observed between left atrial-to-aortic root diameter ratio (LA:Ao) and Body Weight. In addition, the relationship between LVFWd and BMI, although not considered significant, presented P values slightly above 0.05. Obese cats showed higher BPS and VHS than normal cats, which led to an increase in echocardiographic measurements. This study has shown that obesity promoted cardiac function impairment in the studied cats and, therefore, that it is important to monitor these animals since even asymptomatic ones may present changes in cardiac parameters. The study aims at measuring heart rate variability in Holstein cows, fetuses and neonates through a descriptive evaluation of continuous fetomaternal and neonatal electrocardiogram recordings during the perinatal period. Heart rate (HR) and heart rate variability (HRV) were assessed by fetomaternal electrocardiography (ECG). Fetomaternal measurements were taken six times pre-partum and in neonates six times after calving. Heart rate, time-domain variables and frequencydomain variables were analyzed in 23 Holstein cows and 18 neonates.