Selected article for: "cell receptor and TCR gene transfer"
Author: Banu, Nasirah; Chia, Adeline; Ho, Zi Zong; Garcia, Alfonso Tan; Paravasivam, Komathi; Grotenbreg, Gijsbert M.; Bertoletti, Antonio; Gehring, Adam J.
Title: Building and Optimizing a Virus-specific T Cell Receptor Library for Targeted Immunotherapy in Viral Infections
  • Document date: 2014_2_25
    • ID: 44w6omdp_2
    Snippet: Given their critical role in controlling infection, combined with the difficulty in generating virus-specific T cells for adoptive cell therapy, we have explored T cell receptor (TCR) gene transfer to engineer antiviral T cell immunity. By introducing exogenous antigen specific TCRs cloned from patients able to control infection we could engineer fully functional virus-specific T cells to acutely infecting viruses, such as SARS corona virus 10 , .....
    Document: Given their critical role in controlling infection, combined with the difficulty in generating virus-specific T cells for adoptive cell therapy, we have explored T cell receptor (TCR) gene transfer to engineer antiviral T cell immunity. By introducing exogenous antigen specific TCRs cloned from patients able to control infection we could engineer fully functional virus-specific T cells to acutely infecting viruses, such as SARS corona virus 10 , and viruses causing chronic infections, such as HBV 11 . The HBV-specific T cells engineered in patients with chronic infection recognized infected cells and tumor cells expressing viral antigen as a tumor-associated antigen, which is known to occur in HBV and EBV associated cancers 7, 12 .

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