Selected article for: "host range and SARS host range"
Author: Joana Damas; Graham M. Hughes; Kathleen C. Keough; Corrie A. Painter; Nicole S. Persky; Marco Corbo; Michael Hiller; Klaus-Peter Koepfli; Andreas R. Pfenning; Huabin Zhao; Diane P. Genereux; Ross Swofford; Katherine S. Pollard; Oliver A. Ryder; Martin T. Nweeia; Kerstin Lindblad-Toh; Emma C. Teeling; Elinor K. Karlsson; Harris A. Lewin
Title: Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates
  • Document date: 2020_4_18
    • ID: 6ne76rh1_10
    Snippet: Here, we made use of sequenced genomes of 410 vertebrates and protein structural analysis, to identify ACE2 homologs in all vertebrate classes (fishes, amphibians, birds, reptiles, and mammals) that have the potential to serve as a receptor for SARS-CoV-2, and to understand the evolution of ACE2 SARS-CoV-2 S binding sites. Our results reinforce earlier findings on the natural host range of SARS-CoV-2, and predict a broader group of species that m.....
    Document: Here, we made use of sequenced genomes of 410 vertebrates and protein structural analysis, to identify ACE2 homologs in all vertebrate classes (fishes, amphibians, birds, reptiles, and mammals) that have the potential to serve as a receptor for SARS-CoV-2, and to understand the evolution of ACE2 SARS-CoV-2 S binding sites. Our results reinforce earlier findings on the natural host range of SARS-CoV-2, and predict a broader group of species that may serve as a reservoir or intermediate host for this virus. Importantly, many threatened and endangered species were found to be at potential risk for SARS-CoV-2 infection, suggesting that as the pandemic spreads, humans could inadvertently introduce a potentially devastating new threat to these already vulnerable populations, especially for great apes and other primates.

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