Author: Richard, A; Tulasne, D
Title: Caspase cleavage of viral proteins, another way for viruses to make the best of apoptosis Document date: 2012_3_8
ID: 3hxau5vt_18
Snippet: Feline calicivirus (FCV) causes upper respiratory tract disease in cats. FCV capsid protein is synthesized as a precursor further cleaved by the viral protease. However, a 40-kDa product (P40) is also usually observed at late stages of FCV infection and can be abolished with a pan caspase or a caspase 3/7 inhibitor. 45 Accordingly, FCV-infected cells undergo apoptosis as well as caspases 2, 3 and 7 activation. 46 Only caspase 2 and far less effic.....
Document: Feline calicivirus (FCV) causes upper respiratory tract disease in cats. FCV capsid protein is synthesized as a precursor further cleaved by the viral protease. However, a 40-kDa product (P40) is also usually observed at late stages of FCV infection and can be abolished with a pan caspase or a caspase 3/7 inhibitor. 45 Accordingly, FCV-infected cells undergo apoptosis as well as caspases 2, 3 and 7 activation. 46 Only caspase 2 and far less efficiently caspase 6 process FCV capsid protein in vitro at cleavage sites that have not been described yet. As suggested for instance for AMDV, cleavage of the capsid protein might impair particle assembly and participate to viral persistence but this has not been investigated either.
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