Title: 2016 ACVIM Forum Research Abstract Program Document date: 2016_5_31
ID: 2y1y8jpx_51
Snippet: Thirty-one dogs were evaluated. Genotypes included 12 homozygous for the DNA variant and 19 homozygous for the wild type. Median baseline ACE activity was significantly lower for dogs homozygous for the DNA variant (18.05 U/L) than for dogs with the wildtype sequence (27.4 U/L) (P = 0.01). Twenty-seven dogs returned for re-evaluation in 14-21 days. Both genotypes showed a significant suppression of ACE activity on enalapril, (P = 0.0065 DNA varia.....
Document: Thirty-one dogs were evaluated. Genotypes included 12 homozygous for the DNA variant and 19 homozygous for the wild type. Median baseline ACE activity was significantly lower for dogs homozygous for the DNA variant (18.05 U/L) than for dogs with the wildtype sequence (27.4 U/L) (P = 0.01). Twenty-seven dogs returned for re-evaluation in 14-21 days. Both genotypes showed a significant suppression of ACE activity on enalapril, (P = 0.0065 DNA variant dogs; P < 0.0001 wildtype dogs). Median post therapy ACE Activity was not different for the two genotypes (DNA variant, < 5.0 U/L; wildtype dogs <5.0 U/L) (P = 0.24)).
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