2016 ACVIM Forum Research Abstract Program

There was no significant effect of diet on the time to peak leptin concentration in the meal-feeding test (overall P = 0.855), and median times to peak leptin concentration were 15 hours for all diets. In the meal-feeding test, only 3/8 cats significantly exceeded their baseline leptin concentration for each of the high protein and high fat diets, but 7/8 did so for the high carbohydrate diet. In general, leptin concentrations decreased significantly approximately 2 hr after eating in the meal feeding test, but remained relatively constant during ad libitum feeding. When data for all diets were combined, leptin was significantly positively correlated with insulin concentrations during ad libitum feeding (P = 0.008 to 0.036), but only at baseline and at 24 hours in the meal feeding test (P = 0.025 and <0.001, respectively). There were no correlations between leptin and either glucose or NEFA across all diets. Glucose, insulin and NEFA did not account for the decline in leptin soon after feeding in the meal feeding test.