Selected article for: "human population and International license"
Author: Joana Damas; Graham M. Hughes; Kathleen C. Keough; Corrie A. Painter; Nicole S. Persky; Marco Corbo; Michael Hiller; Klaus-Peter Koepfli; Andreas R. Pfenning; Huabin Zhao; Diane P. Genereux; Ross Swofford; Katherine S. Pollard; Oliver A. Ryder; Martin T. Nweeia; Kerstin Lindblad-Toh; Emma C. Teeling; Elinor K. Karlsson; Harris A. Lewin
Title: Broad Host Range of SARS-CoV-2 Predicted by Comparative and Structural Analysis of ACE2 in Vertebrates
  • Document date: 2020_4_18
    • ID: 6ne76rh1_35
    Snippet: Evolution of ACE2 . Variation of ACE2 in the human population is rare (17) . We examined a large set of ACE2 variants for their potential differences in binding to SARS-CoV-2 S and their relationship to selected and accelerated sites. We found rare variants that would result in missense mutations in 7 out of the 25 binding residues (Dataset S2) . Some of those (e.g. E35K with an AF of 0.00001636) could reduce the virus binding affinity, thus pote.....
    Document: Evolution of ACE2 . Variation of ACE2 in the human population is rare (17) . We examined a large set of ACE2 variants for their potential differences in binding to SARS-CoV-2 S and their relationship to selected and accelerated sites. We found rare variants that would result in missense mutations in 7 out of the 25 binding residues (Dataset S2) . Some of those (e.g. E35K with an AF of 0.00001636) could reduce the virus binding affinity, thus potentially lowering the susceptibility to the virus in a very small fraction of 9 . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.16.045302 doi: bioRxiv preprint the population. The analysis suggests that some variants (e.g. D38E) might not affect the binding while others (e.g. S19P) have uncertain effects. Further studies are needed to confirm and correctly address recent discoveries (18, 27, 28) and the data presented here, investigating the possible effect of these rare variants in specific populations.

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