2016 ACVIM Forum Research Abstract Program

Occult UTI appears to be uncommon in cats and can usually be predicted on the basis on an abnormal MSE (bacturia, pyuria). Based on this study, there is little indication to perform a QUC in a cat with no clinical signs of LUTD and an unremarkable MSE. Aside from its association with several inflammatory diseases, the S100A8/A9 calgranulin complex was shown to be expressed by epithelial cells after malignant transformation. In humans, S100A9 or S100A8 have been reported to be up-regulated in patients with prostate carcinoma (PCA) or transitional cell carcinoma (TCC), respectively. Results of the expression of the S100A12 calgranulin in TCC/PCA in humans are ambiguous. Pilot data by our group suggest that the urine canine S100A8/A9-to-S100A12 ratio (uCalR) may have potential as a marker for TCC/PCA in dogs. Further evaluation of urinary S100A8/A9, S100A12, and uCalR in dogs is needed to determine its specificity for a diagnosis of TCC/ PCA. Thus, this study investigated urinary S100A8/A9, S100A12, and uCalR in dogs with TCC/PCA, other urinary tract diseases, or other malignancies.