2016 ACVIM Forum Research Abstract Program

DOGS. David Griffin, Carolyn Warner. Nutramax Laboratories Veterinary Sciences, Inc., Lancaster, SC, USA S-adenosylmethionine (SAMe) is used to support liver function both in companion animals and humans, and is also used in humans for mental and joint health. Previous studies have shown that when SAMe is administered with food there is a substantial decrease in SAMe bioavability (Table 1 ). In a blinded crossover study a new Denamarin Ã’ (Nutramax Laboratories Veterinary Sciences, Inc.) chewable tablet containing a novel formulation of SAMe salt (NMXSS75ATM) was administered to beagle dogs to assess its bioavailability relative to administration with food. Six beagles were dosed after an overnight fast with 225 mg SAMe ion (mean 21.7 mg/kg) in one formulation of the supplement, followed by the other formulation 7 days later administered with food. Plasma values for SAMe before dosing and at 0.5, 1, 2, 4, 6, 8, and 24 hours were determined using an HPLC-ESI-MS/MS assay. With both supplements SAMe plasma levels increased substantially above baseline values (21-38 ng/mL) and returned to baseline after 24 hours. Mean values for C max ,T max , AUC 0-24 and t 1/2 were comparable for both formulations with no statistically significant differences ( Table 2 ). The data indicate that this novel SAMe salt may be used in dogs with equivalent bioavailability when administered with food which may increase owner compliance. Table 1 Effects of Food Consumption on SAMe Tosylate Absorption. Posaconazole is the most active available azole antifungal drug, but absorption and pharmacokinetics are not available to guide dosing regimens in cats. The purpose of this study was to determine pharmacokinetics of oral suspension and IV formulations of posaconazole in cats to determine the feasibility of oral administration for treatment of fungal infections.