2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

This study shows that in this sport horse population, DDSP was associated with lower airway inflammation in a large proportion of cases and can be managed medically. There was a significant increase in PGE 2 levels in ischemic-injured tissues treated with t-TUCB as compared to untreated ischemicinjured tissues (p = 0.0151). The untreated and t-TUCB-treated ischemic-injured tissues had significantly reduced TER compared to the non-ischemic tissues (p < 0.0001 and p = 0.0001). However, there were no statistical differences between ischemicinjured tissues treated with or without t-TUCB. We conclude that t-TUCB is a novel modulator of PG levels, resulting in increased PGE 2 in tissues injured by ischemia without significantly impairing recovery of barrier function. Therefore, t-TUCB may have a future use to treat animals with diseases such as strangulating obstruction.