2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

The conformation guides tumor cells away from the tumor site to an extracranial reservoir. In this study we describe the techniques associated with stereotactically-guided implantation of nanofiber-lined catheters in dogs with naturally occurring and histopathologically confirmed astrocytomas and oligodendrogliomas. The purpose of this study was to evaluate the safety and feasibility of stereotactically- Although this study is small and cannot prove treatment efficacy, these findings support our hypotheses that stereotactic guidance of nanofiber catheters is safe, feasible, and encourages tumor cell migration out of the cranial cavity. This is the first stage in a large clinical trial that ultimately aims to evaluate the safety and efficacy of nanofiber catheters in the treatment of canine brain tumors. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive, safe and painless procedure that is applied in humans to modify the activity of specific neural circuits of the brain. Via electromagnetic induction, a magnetic field generator produces small electric currents on cortical neurons in order to affect neuronal function. The antiepileptic effect of rTMS has been demonstrated in humans with drug-resistant epilepsy. Therefore, a single-blinded randomized placebo-controlled clinical trial was designed to assess the efficacy and safety of rTMS in dogs with drug-resistant idiopathic epilepsy.