Title: 2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018 Document date: 2018_10_25
ID: 60ceejq1_267
Snippet: This study revealed somatic mutations of TP53, PDGFRB, N4BP2, and SH3KBP1 genes in canine HS. We previously reported the high incidence of TP53 gene mutations in canine HS. N4BP2 was reported to interact with BCL3, a target of PI3K/Akt and MAPK/ERK pathways, and SH3KBP1 was shown to induce down-regulation of protein tyrosine kinase that activates PI3K/Akt and MAPK/ERK pathways (Fig. 1) ......
Document: This study revealed somatic mutations of TP53, PDGFRB, N4BP2, and SH3KBP1 genes in canine HS. We previously reported the high incidence of TP53 gene mutations in canine HS. N4BP2 was reported to interact with BCL3, a target of PI3K/Akt and MAPK/ERK pathways, and SH3KBP1 was shown to induce down-regulation of protein tyrosine kinase that activates PI3K/Akt and MAPK/ERK pathways (Fig. 1) .
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