2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

Ten adult, large-breed dogs were recruited from the veterinary community at the Oregon State University College of Veterinary Medicine. Dogs were considered healthy based on history, physical exam, oscillometric blood pressure measurement, transthoracic echocardiography, and a 10-lead electrocardiogram. Each dog also had a baseline 24 hour Holter monitor performed. Sotalol at a dose of 1-2 mg/kg orally q12h was then administered for 12-16 days, followed by a second evaluation including the same diagnostics tests. Physical exam parameters, blood pressure measurements, Holter data, echocardiographic measurements including three-dimensional (3D) left ventricular (LV) volumes and 3D strain were measured at each evaluation. Baseline and post-treatment measurements were assessed for normality, and compared statistically with paired t-tests for normally distributed data and Wilcoxon signed rank tests for non-normally distributed data. 3D data were available for 7/10 dogs. No correction was made for multiple comparisons.