Author: McWhirter, Sarah M.; Barbalat, Roman; Monroe, Kathryn M.; Fontana, Mary F.; Hyodo, Mamoru; Joncker, Nathalie T.; Ishii, Ken J.; Akira, Shizuo; Colonna, Marco; Chen, Zhijian J.; Fitzgerald, Katherine A.; Hayakawa, Yoshihiro; Vance, Russell E.
Title: A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP Document date: 2009_8_31
ID: 3b8b8p61_2
Snippet: One important class of ligands sensed by the innate immune system is nucleic acids. Several distinct nucleic acid sensors have been described and have been found to be distributed to distinct subcellular locations and exhibit distinct specificities for different nucleic acid ligands. A common theme is that nucleic acid sensors tend to induce expression of type I IFN genes and, thus, appear to be particularly important for initiating immune respon.....
Document: One important class of ligands sensed by the innate immune system is nucleic acids. Several distinct nucleic acid sensors have been described and have been found to be distributed to distinct subcellular locations and exhibit distinct specificities for different nucleic acid ligands. A common theme is that nucleic acid sensors tend to induce expression of type I IFN genes and, thus, appear to be particularly important for initiating immune responses to viruses.
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