Author: McWhirter, Sarah M.; Barbalat, Roman; Monroe, Kathryn M.; Fontana, Mary F.; Hyodo, Mamoru; Joncker, Nathalie T.; Ishii, Ken J.; Akira, Shizuo; Colonna, Marco; Chen, Zhijian J.; Fitzgerald, Katherine A.; Hayakawa, Yoshihiro; Vance, Russell E.
Title: A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP Document date: 2009_8_31
ID: 3b8b8p61_29
Snippet: To obtain a preliminary indication as to whether adaptive immune responses could be stimulated by c-di-GMP, we immunized mice with human serum albumin (HSA) and tested whether coinjected c-di-GMP could function as an adjuvant, as previously reported (Ebensen et al., 2007; DAI, and at least one of these uncharacterized DNA sensors, or another independent sensor, may respond to c-di-GMP......
Document: To obtain a preliminary indication as to whether adaptive immune responses could be stimulated by c-di-GMP, we immunized mice with human serum albumin (HSA) and tested whether coinjected c-di-GMP could function as an adjuvant, as previously reported (Ebensen et al., 2007; DAI, and at least one of these uncharacterized DNA sensors, or another independent sensor, may respond to c-di-GMP.
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