Title: 2016 ACVIM Forum Research Abstract Program Document date: 2016_5_31
ID: 2y1y8jpx_197
Snippet: Three dogs required dose reductions of carboplatin secondary to neutropenia, and two required drug holidays during TP treatment. No dogs were withdrawn from the study due to toxicity. Seven dogs developed local recurrence or metastasis as the first event. One dog was withdrawn from the study due to owner wishes, one was euthanized due to osteoarthritis, and one developed lymphoma with no evidence of OSA metastasis. There was no significant differ.....
Document: Three dogs required dose reductions of carboplatin secondary to neutropenia, and two required drug holidays during TP treatment. No dogs were withdrawn from the study due to toxicity. Seven dogs developed local recurrence or metastasis as the first event. One dog was withdrawn from the study due to owner wishes, one was euthanized due to osteoarthritis, and one developed lymphoma with no evidence of OSA metastasis. There was no significant difference in MMP or VEGF (absolute or platelet-corrected) at any time point, and there was no correlation of these values with OSA-free survival or OS. Median OSA-free survival was 183 days (range, 55-576) and OS was 250 days (range, 80-882).
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