2016 ACVIM Forum Research Abstract Program

In conclusion, this study suggests that fecal D-and L-lactate are increased in dogs with exocrine pancreatic insufficiency, regardless of enzyme replacement treatment status. Also, lactateproducing bacterial groups were altered in dogs with EPI when compared to healthy control dogs. Beta-hydroxybutyrate (BHB), a ketone body, is synthesized in the liver from acetyl CoA and is utilized as an energy source when glucose supplies are limited. BHB has been demonstrated to play a role in the oxidative stress response by the binding of histone deacetylase and in the suppression of inflammatory disease by antagonizing the cryopyrin inflammasome (NALP3). Previous untargeted metabolomics studies of both human and canine patients with idiopathic inflammatory bowel disease have shown significantly higher serum concentrations of BHB in diseased patients than in healthy controls, suggesting that BHB may be useful as a biomarker for inflammatory bowel disease. In this study, we investigated serum BHB concentrations in healthy dogs and dogs with two types of chronic enteropathy: food responsive diarrhea and steroid-responsive diarrhea.