2016 ACVIM Forum Research Abstract Program

Tissue factor activated TEG was performed in six specific pathogen free (SPF) sex and age-matched healthy Beagles at three different time points where the variables reaction time (R), clotting time (K), rate of clot formation (a), and maximum amplitude (MA) were recorded. Adenosine diphosphate (ADP)-induced and arachidonic acid (AA)-induced platelet aggregometry in addition to platelet count, hematocrit, and fibrinogen were also performed concurrently. APTT, OSPT, antithrombin activity, and D-dimer concentrations were measured on the first day of the study. A oneway random effects model was used to analyze the following variables; R, K, a, MA, area under the curve for ADP (AUC ADP ), and area under the curve for AA (AUC AA ). Variance components were created from the random effects model and used to calculate coefficients of variation for interindividual variability (CV G ) and intraindividual variability (CV I ). A repeated measures ANOVA was performed on the platelet count, hematocrit, and fibrinogen over the three time points with P < 0.05 considered significant.