Selected article for: "A59 infection and class expression"
Title: Coronavirus induction of class I major histocompatibility complex expression in murine astrocytes is virus strain specific
  • Document date: 1994_9_1
    • ID: 4bf8eiix_29
    Snippet: The mechanism by which A59, MHV-3, and the A59like recombinant MHV strains induce class I expression in astrocytes is currently unknown. Massa et al. (62, 63) have shown that MHC class I promoter activity is upregulated in astrocytes treated with IFN-y and that the upregulation is associated with an increase in the binding activities of the MHC class I regulatory element (MHC-CRE) and the IFN consensus sequence (ICS). Whether or not these regulat.....
    Document: The mechanism by which A59, MHV-3, and the A59like recombinant MHV strains induce class I expression in astrocytes is currently unknown. Massa et al. (62, 63) have shown that MHC class I promoter activity is upregulated in astrocytes treated with IFN-y and that the upregulation is associated with an increase in the binding activities of the MHC class I regulatory element (MHC-CRE) and the IFN consensus sequence (ICS). Whether or not these regulatory elements are engaged by A59 infection remains to be determined.

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