Title: 2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018 Document date: 2018_10_25
ID: 60ceejq1_354
Snippet: In conclusion, intestinal biopsies from clinically healthy cats commonly show abnormal findings using histopathology, immunohistochemistry, and clonality testing without any apparent clinical significance. While the sensitivity of clonality tests is reported to be high, these results imply that further assessment of the specificity of this diagnostic modality is warranted. A total of 2,349 spots were identified, of which 9 were differentially exp.....
Document: In conclusion, intestinal biopsies from clinically healthy cats commonly show abnormal findings using histopathology, immunohistochemistry, and clonality testing without any apparent clinical significance. While the sensitivity of clonality tests is reported to be high, these results imply that further assessment of the specificity of this diagnostic modality is warranted. A total of 2,349 spots were identified, of which 9 were differentially expressed with a ≥ 2-fold change between healthy cats and cats with IBD and SCL (p ≤ 0.01). Eight of these 9 spots were also differentially expressed between cats with IBD and those with SCL (p ≤ 0.04). LC-MS/MS identified proteins of the annexin and apolipoprotein families, and malate dehydrogenases in the differentially expressed spots.
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