2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

Median sI-CAM-1 serum concentrations were significantly higher in dogs with AKI (43.6 ng/ml, n = 18) and in dogs with LPHS (64.2 ng/ml, n = 14) compared to heathy controls (15.8 ng/ml, ; n = 31; p < 0.001). Median sI-CAM-1 was higher in dogs with leptospirosis without LPHS (37.6 ng/ml, IQR 20.9-53.4, n = 10) compared controls, and lower than in the LPHS group, but these differences did not reach statistical significance. Few day 3 samples were available for analysis, but showed similar trends with highest sI-CAM-1 in dogs with LPHS (87.5 ng/ml, IQR 44.1-101.7; n = 5) compared to healthy controls, dogs with AKI (21.9 ng/ml, IQR 10. 5-71.3; n = 5) and leptospirosis without LPHS (26.2 ng/ml, IQR 23. 2-29.3; n = 2) . However, only the difference between healthy and LPHS group was statistically significant (p = 0.015). There was no significant association between sI-CAM-1, disease group and outcome. Day 1 sI-CAM-1 predicted the development of LPHS with reasonable accuracy (AUC 0.79; sensitivity 79%, CI 49-95; specificity 73%, CI 60-84).