2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

We concluded that because there are no reliable clinical indices by which biofilm-formation can be ruled out, consideration should be given to the possibility of biofilm-formation whenever E. coli UTIs are diagnosed. Additionally, the association of MDR and non-biofilmforming E. coli may antimicrobial tolerance conferred by biofilm formation. The uremia associated with chronic kidney disease (CKD) has been shown to profoundly affect the composition of the gut microbiome in people and rat models. Toxic products generated by dysbiosis may contribute to morbidity and progression of CKD.Indoxyl sulfate (IS) and p-cresol sulfate (pCS) are uremic toxins produced by colonic bacteria. The first study objective was to compare the fecal microbiome of healthy, older (> 8 years) cats (n = 11) and cats with stable CKD (IRIS stage 2-4) (n = 30). The second objective was to measure serum IS and pCS in healthy, older cats (n = 10) and compare to CKD cats (n = 28).