Author: Liu, Zhida; Zhou, Hang; Wang, Wenjun; Tan, Wenjie; Fu, Yang-Xin; Zhu, Mingzhao
Title: A novel method for synthetic vaccine construction based on protein assembly Document date: 2014_12_1
ID: 2tazu4y6_6
Snippet: In the current work, we have tested the novel method of proteinassembly based vaccine construction. Employing the optimized SpyTag/SpyCatcher system, we have assembled vaccines composed of a single-chain antibody against DEC205 and model antigens (including the model T-cell epitope chicken ovalbumin 257-264 (OVA 8 ) and tick-borne encephalitis virus envelope protein domain 3 (TBEV ED3)) 22, 23 . This new synthetic vaccine was shown to be fully fu.....
Document: In the current work, we have tested the novel method of proteinassembly based vaccine construction. Employing the optimized SpyTag/SpyCatcher system, we have assembled vaccines composed of a single-chain antibody against DEC205 and model antigens (including the model T-cell epitope chicken ovalbumin 257-264 (OVA 8 ) and tick-borne encephalitis virus envelope protein domain 3 (TBEV ED3)) 22, 23 . This new synthetic vaccine was shown to be fully functional and to generate efficient cytotoxic T-cell and antibody responses. Thus, this protein-based synthetic vaccine strategy may be a significant improvement over the conventional gene-based synthetic vaccine strategy and may serve as a useful platform for faster and easier vaccine development.
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