Author: Xia, Shuai; Yan, Lei; Xu, Wei; Agrawal, Anurodh Shankar; Algaissi, Abdullah; Tseng, Chien-Te K.; Wang, Qian; Du, Lanying; Tan, Wenjie; Wilson, Ian A.; Jiang, Shibo; Yang, Bei; Lu, Lu
Title: A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike Document date: 2019_4_10
ID: 3c5ab73l_37
Snippet: One intriguing question is why only EK1 and the HR2 from OC43 manifested "pan-CoV" inhibitory activity, while HR2 from other HCoVs did not. HR2s from ï¡-HCoVs are substantially longer than those from ï¢-HCoVs (Fig. 1C) , and docking of HR2s from 229E and NL63 onto the 3HR1 cores of ï¢-HCoVs resulted in severe steric clashes (figure not shown). It is thus understandable why the HR2s from 229E and NL63 would not have broad-spectrum activity towa.....
Document: One intriguing question is why only EK1 and the HR2 from OC43 manifested "pan-CoV" inhibitory activity, while HR2 from other HCoVs did not. HR2s from ï¡-HCoVs are substantially longer than those from ï¢-HCoVs (Fig. 1C) , and docking of HR2s from 229E and NL63 onto the 3HR1 cores of ï¢-HCoVs resulted in severe steric clashes (figure not shown). It is thus understandable why the HR2s from 229E and NL63 would not have broad-spectrum activity toward ï¢-HCoVs (Fig. 1D) .
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