Title: 2016 ACVIM Forum Research Abstract Program Document date: 2016_5_31
ID: 2y1y8jpx_659
Snippet: Five Standardbred mares (12-13 years-old; 460-530 kg) were randomly assigned to receive one of 5 doses of CoCl 2 (4, 2, 1, 0.5, or 0.25 mg/kg) as an intravenous bolus (infused over 1 minute) once weekly for 5 weeks. Prior to each dose, animals were instrumented with pulmonary artery and right atrial catheters, a transverse facial artery catheter, two external jugular venous catheters, an indwelling urinary catheter, and electrocardiography leads......
Document: Five Standardbred mares (12-13 years-old; 460-530 kg) were randomly assigned to receive one of 5 doses of CoCl 2 (4, 2, 1, 0.5, or 0.25 mg/kg) as an intravenous bolus (infused over 1 minute) once weekly for 5 weeks. Prior to each dose, animals were instrumented with pulmonary artery and right atrial catheters, a transverse facial artery catheter, two external jugular venous catheters, an indwelling urinary catheter, and electrocardiography leads. Physical examination parameters, blood pressure (systolic arterial pressure [SAP] , diastolic arterial pressure [DAP] , and mean arterial pressure [MAP]), cardiac output, and qualitative ECG assessment were evaluated every 5-10 minutes for 4 hours immediately after administration of the first and fifth weekly doses of CoCl 2 .
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