2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

was detected. These findings suggest that sequential qualitative evaluation of urinary proteins can add more information to interpretation of UP/C results. Identification of the damaged nephron segment that caused a specific pattern of protein loss could help refine the diagnosis of a specific renal disease as well as to optimize therapy. Importantly, the detection of albumin, RBP and VDBP in urine samples with normal UP/C might serve as an early marker of glomerular and tubular injury. respectively. This study aims at describing P and QT dispersions, as well electrocardiographic changes observed in dogs with CKD stage IV undergoing IHD. The animals were classified considering serum creatinine (> 5mg/dL), urinary protein/creatinine ratio (> 0.5) and systolic blood pressure (> 160mmHg). Ten dogs weighing 15-30 kg were included in the study and electrocardiographic examinations were performed before and after the first three sessions of IHD. The results were analyzed using ANOVA with Friedman's test, considering a significance level of 5%. There were significant increases in values for P maximum (p = 0.011), QT maximum (p = 0.002), QT minimum (p = 0.023), however, the changes in P and QT dispersions were not significant (p> 0.05). There were increases in PR intervals (p = 0.019), QT intervals (p = 0.034) and a decrease in the amplitude of the R wave (p = 0.002). After the second session, three dogs (30%) developed sinus arrest and another three (30%) developed supraventricular arrhythmias. The results obtained suggest that employing IHD in dogs may cause electrocardiographic changes such as arrhythmias, interferences in atrioventricular conduction, as well as in the ventricular depolarization and repolarization process. These findings highlight the importance of electrophysiological monitoring in animals submitted to this therapeutic modality. sodium/1000 kcal) has been reported to increase urinary calcium while concomitantly increasing water intake and consequently urine volume when compared to a food containing approximately 0.4% (1g sodium/1000 kcal). When foods with similar Ca, P and Mg restriction but relatively high (3.5g/1000 kcal) and low (1g/1000 kcal) sodium content were compared, it was observed that relative supersaturation (RSS) for calcium oxalate was similar and calcium excretion was significantly greater for the high sodium food. 3 This suggests that a benefit ascribed to lower urinary saturation due to increased urinary water is offset by increased urine calcium content. Long term studies have not been performed in cats comparing RSS for calcium oxalate and recurrence rates for uroliths; however a correlation does exist in humans. Another surrogate for calcium oxalate risk, the Bonn Risk Index as described by Laube et al, has been proposed as a better predictor of future calcium oxalate risk than relative super saturation. 4, 5 This study examines low and high sodium feline dry foods by using the calcium oxalate titration (COT) test first described by Davidson 6 , which is similar to the human Bonn Risk Index test. In the COT test, centrifuged, unaltered, body temperature urine is titrated with a sodium oxalate solution and monitored at 585nm until precipitation occurs. The COT value is determined by dividing the urine [Ca 2+ ] by the resultant amount of oxalate added at the point of precipitation.