2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

There was a significant decrease in calcium oxalate supersaturation even with these limitations suggesting determination of relative PA using two agonists (adenosine diphosphate; ADP and arachidonic acid; ASPI) and a saline control was performed in six healthy clientowned dogs at baseline and 1 week following clopidogrel administration to establish cut-off values to identify responders (R) or nonresponders (NR). A decrease of ≥ 60% for ADP at 1 or 3 hours post clopidogrel administration defined a R. PA was performed in PLN dogs at baseline and 1, 6, and 12 weeks following clopidogrel or aspirin administration. Drug concentrations and PA were measured at 1 and 3 hours post clopidogrel administration (at 1 week or 6 weeks) in both healthy and PLN dogs. Fourteen dogs were enrolled; ten PLN dogs received clopidogrel alone, three received aspirin alone, and one dog was started on aspirin but was switched to clopidogrel. Repeated measures (RM) analysis (one-way ANOVA) was performed and subsequent time points (1, 6, and 12 Chronic kidney disease (CKD) in dogs is a common clinical entity characterized by a marked decrease in renal function. In humans, there are several reports that uremia caused by renal failure affects the oral and fecal microbiomes, but there is a lack of information on the oral and fecal microbiomes in dogs with CKD. Therefore, the objective of the present study was to examine the changes in the oral and fecal microbiomes in CKD dogs.