2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

This study evaluated the effects of 3% HHES in controlled hemorrhagic shock dog model compared to four conventional fluids in three aspects: volume expansion, systemic and tissue perfusion response, and acid-base status. In the aspect of volume expansion, LRS, 6% HES, and 3% HHES resuscitated significantly larger volume than 7% HS and 7% HHES but LRS and 6% HES were considered as overexpansion of intravascular volume (p < 0.05). Hemodynamic data coincides with volumetric results. Three percent HHES as well as other four fluids provided sufficient systemic oxygenation and perfusion yet the further examination should be conducted in hemorrhagic shock model based on oxygen debt. Infusion of 3% HHES was beneficial to the acidotic state of hemorrhagic shock without dilutional acidosis owing to transient hypernatremia and hyperchloremia.