Selected article for: "bind protein and present study"
Author: Liu, Zhida; Zhou, Hang; Wang, Wenjun; Tan, Wenjie; Fu, Yang-Xin; Zhu, Mingzhao
Title: A novel method for synthetic vaccine construction based on protein assembly
  • Document date: 2014_12_1
    • ID: 2tazu4y6_15
    Snippet: The results of the present study showed that the optimized SpyCatcherDN exhibits much lower immunogenicity than wildtype SpyCatcher does, without influencing the ability to bind to aDEC205-SpyTag. The antigen-containing fusion protein Spy-CatcherDN-OVA 8 -ED3 can also efficiently bind to aDEC205-SpyTag, without affecting the targeting ability of DEC205 either in vitro or in vivo. Subsequent results from the animal study showed that an aDEC205 add.....
    Document: The results of the present study showed that the optimized SpyCatcherDN exhibits much lower immunogenicity than wildtype SpyCatcher does, without influencing the ability to bind to aDEC205-SpyTag. The antigen-containing fusion protein Spy-CatcherDN-OVA 8 -ED3 can also efficiently bind to aDEC205-SpyTag, without affecting the targeting ability of DEC205 either in vitro or in vivo. Subsequent results from the animal study showed that an aDEC205 adduct vaccine can elicit enhanced T-cell and Bcell responses. Furthermore, this new method is highly translatable; in fact, our unpublished data demonstrated its usefulness and efficacy in the construction of other vaccines.

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