Author: Liu, Zhida; Zhou, Hang; Wang, Wenjun; Tan, Wenjie; Fu, Yang-Xin; Zhu, Mingzhao
Title: A novel method for synthetic vaccine construction based on protein assembly Document date: 2014_12_1
ID: 2tazu4y6_16
Snippet: In summary, we have established a convenient and efficient platform for conjugating antigens of interest to specific antibodies using the optimized SpyTag/SpyCatcher system. This platform could be very useful in antigen screening and vaccine development against infectious diseases and cancers. Furthermore, the use of this method is probably not limited to vaccine development; it may have broader applications. Antibodies and recombinant proteins h.....
Document: In summary, we have established a convenient and efficient platform for conjugating antigens of interest to specific antibodies using the optimized SpyTag/SpyCatcher system. This platform could be very useful in antigen screening and vaccine development against infectious diseases and cancers. Furthermore, the use of this method is probably not limited to vaccine development; it may have broader applications. Antibodies and recombinant proteins have been extensively studied in animal and clinical studies of various diseases for preventative and therapeutic purposes. The strategy proposed in our current study may provide an easy and efficient protein-engineering method for generating bi-specific antibodies and producing multifunctional fusion proteins or antibodies.
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