Author: Abes, Rachida; Moulton, Hong M.; Clair, Philippe; Yang, Sung-Tae; Abes, Said; Melikov, Kamran; Prevot, Paul; Youngblood, Derek S.; Iversen, Patrick L.; Chernomordik, Leonid V.; Lebleu, Bernard
Title: Delivery of steric block morpholino oligomers by (R-X-R)(4) peptides: structure–activity studies Document date: 2008_9_16
ID: 5j496cx0_2
Snippet: We have recently described a new (R-Ahx-R) 4 -CPP (in which Arg residues are interspersed with nonnatural 6-aminohexanoic acid amino-acid spacers) which leads to efficient splicing correction at low concentration in the absence of endosomolytic agents. (R-Ahx-R) 4 is less cytotoxic and much more active to deliver splice correcting PMO and PNA in vitro than the parent oligoarginine (R n ) peptide and than the prototypic Tat 48-60 peptide (4) . Imp.....
Document: We have recently described a new (R-Ahx-R) 4 -CPP (in which Arg residues are interspersed with nonnatural 6-aminohexanoic acid amino-acid spacers) which leads to efficient splicing correction at low concentration in the absence of endosomolytic agents. (R-Ahx-R) 4 is less cytotoxic and much more active to deliver splice correcting PMO and PNA in vitro than the parent oligoarginine (R n ) peptide and than the prototypic Tat 48-60 peptide (4) . Importantly, (R-Ahx-R) 4 -PMO conjugates also lead to efficient exon skipping in murine and dog Duchenne muscular dystrophy (DMD) models (5) and inhibit the replication of viruses in several murine models (6) (7) (8) (9) .
Search related documents:
Co phrase search for related documents- amino acid and low concentration: 1, 2, 3, 4
- amino acid and murine model: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- amino acid and muscular dystrophy: 1
- amino acid and splicing correction: 1
- amino acid and virus replication: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
- Arg residue and splicing correction: 1
- DMD model and Duchenne muscular dystrophy: 1, 2, 3
- DMD model and murine model: 1
- DMD model and muscular dystrophy: 1, 2, 3
- Duchenne muscular dystrophy and exon skip: 1
- Duchenne muscular dystrophy and murine model: 1, 2
- Duchenne muscular dystrophy and muscular dystrophy: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70
- Duchenne muscular dystrophy and splicing correction: 1
- exon skip and muscular dystrophy: 1
Co phrase search for related documents, hyperlinks ordered by date