Author: Abes, Rachida; Moulton, Hong M.; Clair, Philippe; Yang, Sung-Tae; Abes, Said; Melikov, Kamran; Prevot, Paul; Youngblood, Derek S.; Iversen, Patrick L.; Chernomordik, Leonid V.; Lebleu, Bernard
Title: Delivery of steric block morpholino oligomers by (R-X-R)(4) peptides: structure–activity studies Document date: 2008_9_16
ID: 5j496cx0_58
Snippet: The (R-Acy-R) 4 -PMO conjugate (compound 7 with a C8 linker) did not follow the ranking observed for other conjugates in this series since it had lower heparin-binding affinity but corrected splicing less efficiently than (R-Ahx-R) 4 -PMO. This might be explained by the higher hydrophobicity of its longer spacer as evidenced by an increased retention on a C18-affinity column ( Figure 2B )......
Document: The (R-Acy-R) 4 -PMO conjugate (compound 7 with a C8 linker) did not follow the ranking observed for other conjugates in this series since it had lower heparin-binding affinity but corrected splicing less efficiently than (R-Ahx-R) 4 -PMO. This might be explained by the higher hydrophobicity of its longer spacer as evidenced by an increased retention on a C18-affinity column ( Figure 2B ).
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