Selected article for: "general procedure and reaction mixture"
Author: Ouahrouch, Abdelaaziz; Taourirte, Moha; Schols, Dominique; Snoeck, Robert; Andrei, Graciela; Engels, Joachim W.; Lazrek, Hassan B.
Title: Design, Synthesis, and Antiviral Activity of Novel Ribonucleosides of 1,2,3-Triazolylbenzyl-aminophosphonates
  • Document date: 2015_11_17
    • ID: 25dwlzpy_21
    Snippet: The compounds 2a-j were synthesized by reaction of commercial (Sigma-Aldrich) 4-[(trimethylsilyl)ethynyl]benzaldehyde 1 (1 mmol), diethylphosphite (1.2 equiv.), and corresponding amine (1.2 equiv.) in acetonitrile (3 mL) using molecular iodine (0.2 equiv.) as catalyst at room temperature, the reaction mixture was stirred at room temperature for 1 h. Then, the solvent was removed under reduced pressure. The resulting residue was purified by column.....
    Document: The compounds 2a-j were synthesized by reaction of commercial (Sigma-Aldrich) 4-[(trimethylsilyl)ethynyl]benzaldehyde 1 (1 mmol), diethylphosphite (1.2 equiv.), and corresponding amine (1.2 equiv.) in acetonitrile (3 mL) using molecular iodine (0.2 equiv.) as catalyst at room temperature, the reaction mixture was stirred at room temperature for 1 h. Then, the solvent was removed under reduced pressure. The resulting residue was purified by column chromatography using ethyl acetate/hexane as eluent. 13 General procedure for the synthesis of diethyl [(4-(2,3,5tri-O-benzoyl-b-D-ribofuranos-1-yl)-1,2,3-triazol-4-yl)(aryl or alkylamino)(phenyl)methyl]phosphonates 4a-j

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