Title: 2016 ACVIM Forum Research Abstract Program Document date: 2016_5_31
ID: 2y1y8jpx_50
Snippet: We evaluated dogs with pre-CHF MMVD and a vertebral heart score of ≥ 11, presenting to the NCSU CVM in the last 18 months. Dogs were genotyped for the ACE polymorphism. Serum samples were collected and analyzed for ACE activity measurement by radioimmunoassay. Dogs were prescribed enalapril, 0.5 mg/kg orally twice a day, and revaluated in 14-21 days with a second measurement of ACE activity. A t test was used to compare ACE activity in the wild.....
Document: We evaluated dogs with pre-CHF MMVD and a vertebral heart score of ≥ 11, presenting to the NCSU CVM in the last 18 months. Dogs were genotyped for the ACE polymorphism. Serum samples were collected and analyzed for ACE activity measurement by radioimmunoassay. Dogs were prescribed enalapril, 0.5 mg/kg orally twice a day, and revaluated in 14-21 days with a second measurement of ACE activity. A t test was used to compare ACE activity in the wildtype (normal canine sequence) and DNA variant groups at baseline and after therapy. A paired t test was used to compare each genotype's ACE activity before and after therapy.
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