2016 ACVIM Forum Research Abstract Program

Distributions of leptin variables in the ad libitum and mealfeeding tests were similar across dietary groups after consumption of the washout diet for 5 weeks. Mean baseline concentrations (average of À30 and À5 minutes values), mean concentrations over 24 hours (mean 24-h), and peak leptin concentrations in the meal feeding test varied significantly by diet (overall P < 0.001 to 0.027). Baseline, mean 24-h and peak leptin concentrations for the high fat diet were significantly higher than for the high protein diet, and for baseline and mean 24-h, for the high carbohydrate diet. A similar pattern was observed in the ad libitum feeding test with highest leptin concentrations in cats consuming the high fat diet. In general, leptin concentrations after consuming the high carbohydrate diet were not significantly different from the high protein diet, but if they differed, leptin concentration for the high carbohydrate diet was higher compared to the high protein.