2016 ACVIM Forum Research Abstract Program

SDMA has previously been shown to correlate well to GFR, and can be elevated prior to creatinine in some animals, making it an excellent marker for CKD in felines. However, this highthroughput immunoturbidometric Cystatin C assay did not differentiate between animals with elevated creatinine, and cannot be recommended for aid in diagnosing CKD in felines. In humans and cats with chronic kidney disease (CKD), fibroblast growth factor-23 (FGF-23) has been associated with disease progression and development of renal secondary hyperparathyroidism (RHPT). In humans, elevations in FGF-23 often precede hyperphosphatemia and RHPT. The objectives of this study were to measure plasma FGF-23 concentrations in healthy dogs and dogs with CKD and to determine its association with serum creatinine, phosphorus, and parathyroid hormone (PTH) concentrations.