2016 ACVIM Forum Research Abstract Program

Dogs with TCC/PCA had significantly higher urinary S100A8/ A9 and S100A12 concentrations than all other groups of dogs (all P < 0.016) except for dogs with UTI, whereas uCalR was significantly higher in TCC/PCA dogs compared to only those with a UTI (P < 0.001). Treatment-na€ ıve TCC/PCA patients and UTI dogs were best distinguished by a uCalR of ≥9.1 (sensitivity: 91%, specificity: 60%). A urine canine S100A8/A9 concentration (normalized against the urine specific gravity [USG]) of ≥109.9 had the highest sensitivity (96%) and specificity (66%) to diagnose treatment-na€ ıve TCC/PCA dogs from all other groups of dogs, and the specificity increased to 75% if a UTI had been excluded. Using a urine S100A8/A9 concentration (normalized against USG) of ≥109.9 to screen dogs ≥6 years of age for TCC/PCA (estimated prevalence: <1%) yielded a PPV of 4% and a NPV of 100%.