2016 ACVIM Forum Research Abstract Program

While larger case numbers are needed, the preliminary results suggest that feeding Purina Veterinary Diet UR UrinaryÃ’ St/OxÃ’ can successfully dissolve cystoliths that are likely struvite and may lessen risk of recurrence of struvite and calcium oxalate cystoliths. The purpose of this crossover design study was to determine if 3 different resuscitative fluid therapy protocols would increase N-terminal proBNP (NT proBNP) levels in healthy dogs. The protocols included a balanced isotonic replacement crystalloid solution (Normosol R) administered at 90 mL/kg/h over one hour, a 7.2% hypertonic saline bolus administered at 5 mL/kg over 15 minutes, and a 6% hydroxyethyl starch fluid bolus (Voluven Ã’) administered at 20 mL/kg over 30 minutes. Serum NT-proBNP concentrations were measured in 6 healthy purpose bred dogs prior to fluid administration and then 0.5, 1, 1.5, 2, 4, 8, 12, 18, 24, 36 and 48 hours after receiving one of the three fluid therapy protocols. Each dog was randomly assigned to receive a different fluid protocol each week for 3 weeks, allowing a 5-day washout period between treatment protocols. Serum NT-proBNP concentration was significantly more elevated from baseline in dogs receiving 90 mL/kg/hr of crystalloid solution compared to dogs receiving hypertonic saline or hydroxyethyl starch boluses. None of the fluid therapy protocols caused elevations of serum NT-proBNP above the previously reported cut-off concentration used to discriminate between dogs with congestive heart failure and dogs with primary respiratory disease.