Clinical Impact of Mixed Respiratory Viral Infection in Children with Adenoviral Infection

Lee, Hyun Jun; Seo, Young Eun; Han, Seung Beom; Jeong, Dae Chul; Kang, Jin Han

Previous studies have reported significant association between younger age and coinfection in ADV infection, as is the case with other respiratory viral infections [18, 19, 21, 22] , and the present study also showed a significant increase in coinfection frequency in children younger than 24 months of age than that in older children. In addition, the increased LRTI cases we report in the coinfection group have been reported previously [19, 24] . In the present study, we observed a significant association between the presence of underlying medical conditions and coinfection, although this has not been a significant coinfection associated factor in some other previous studies [18, 22] . Eleven of 13 children with underlying medical conditions in the present study had a preterm birth history, and eight of them had a previous history of BPD. These medical conditions may affect the lower respiratory tract function during infancy and early childhood. Amongst younger age, LRTI, and underlying medical conditions, factors related to coinfection based on a univariate analysis, only the younger age was associated independently with coinfection following a logistic regression test.