2016 ACVIM Forum Research Abstract Program

In conclusion, an H 2 -antagonist, famotidine increases gastric pH by reducing acid production by parietal cells. This study showed that a single intravenous dose of famotidine administered at 0.4 mg/kg is effective at increasing the abomasal outflow pH of adult cattle for up to 4 hours as compared to saline control. When administered every 8 hours, to mimic clinical therapeutic recommendation, the abomasal outflow pH was significantly higher for 4 hours after administration of the first dose; however, the effect seemed to decrease after each subsequent dose. Results of this study indicate that famotidine administered at 0.4 mg/kg IV is effective at raising the abomasal pH and may be an effective treatment for abomasal ulceration in adult cattle. However, the efficacy of treatment may decrease over time or may require more frequent dosing to sustain elevated abomasal pH. The study objective was to evaluate the effects of patient age on aminoglycoside pharmacokinetics in young-adult (≤5 years) and aged (≥14 years) healthy alpacas, receiving a single 6.6 mg/kg intravenous injection of gentamicin (Henry ScheinÒ). Heparinized plasma samples were obtained at designated time-points following drug administration and frozen at À80°C until assayed by a validated immunoassay (QMSÒ). Gentamicin plasma concentrations versus time plots were analyzed using a two-compartment model and commercial software (WinNonlin-v6.4). Data were compared between age-groups using independent samples t-test; P < 0.05 considered significant.