Title: 2015 ACVIM Forum Research Abstract Program Document date: 2015_5_27
ID: 3pnuj5ru_719
Snippet: A measured amount of injectable ibuprofen was apportioned in 500 mL of canine whole blood (blood volume equivalent to a 5 kg dog) and incubated for 30 minutes at 38.5°C. TPE was performed over 2 hours to achieve filtration of 1.5 plasma volumes. Heparinized blood (2 mL) and effluent (1 mL) samples were collected at T = 0, 0.5, 1, and 2 hours. All samples were centrifuged (500 g for 5 minute) and the serum and RBC fractions were separated and col.....
Document: A measured amount of injectable ibuprofen was apportioned in 500 mL of canine whole blood (blood volume equivalent to a 5 kg dog) and incubated for 30 minutes at 38.5°C. TPE was performed over 2 hours to achieve filtration of 1.5 plasma volumes. Heparinized blood (2 mL) and effluent (1 mL) samples were collected at T = 0, 0.5, 1, and 2 hours. All samples were centrifuged (500 g for 5 minute) and the serum and RBC fractions were separated and collected. Ibuprofen concentrations were determined by high performance liquid chromatography. Percentage removal and sieving coefficients were calculated to assess ibuprofen clearance from blood.
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