2015 ACVIM Forum Research Abstract Program

A mean (AE SD) increase in SAP of 38.8 AE 3.7 mm Hg was obtained after administration of ANG-I at baseline. There was a significant effect of benazepril dose (P = 0.004) and time (P = 0.004) on the percentage of inhibition of the systolic pressor response to ANG-I. Regardless of dose, the percentage of inhibition was significantly greater 2 hour after administration of benazepril compared to 12 hour and 24 hour. The percentage of inhibition after administration of benazepril at 1.0 mg/kg (46.6 AE 18.9%) was significantly greater than that achieved after 0.5 mg/kg but not significantly different from that achieved after higher dosages.