Author: Monika Litvinukova; Carlos Talavera-Lopez; Henrike Maatz; Daniel Reichart; Catherine L. Worth; Eric L. Lindberg; Masatoshi Kanda; Krzysztof Polanski; Eirini S. Fasouli; Sara Samari; Kenny Roberts; Elizabeth Tuck; Matthias Heinig; Daniel DeLaughter; Barbara McDonough; Hiroko Wakimoto; Joshua M. Gorham; Emily Nadelmann; Krishnaa T. Mahbubani; Kourosh Saeb-Parsy; Giannino Patone; Joseph J Boyle; Hongbo Zhang; Hao Zhang; Anissa Viveiros; Gavin Oudit; Omer Bayraktar; J. G. Seidman; Christine Seidman; Michela Noseda; Norbert Hubner; Sarah A. Teichmann
Title: Cells and gene expression programs in the adult human heart Document date: 2020_4_5
ID: 1ilforzm_4
Snippet: The cellular composition of the adult human heart, their anatomical specificities, molecular signatures, intercellular networks and spatial relationships between the various cardiac cells remain largely unknown. Single-cell and single-nuclei transcriptomics (scRNA-Seq, snRNA-seq) and multiplex smFISH imaging now enable us to address these issues at unprecedented resolution 3 . These technologies illuminate the coordinated communication of cells w.....
Document: The cellular composition of the adult human heart, their anatomical specificities, molecular signatures, intercellular networks and spatial relationships between the various cardiac cells remain largely unknown. Single-cell and single-nuclei transcriptomics (scRNA-Seq, snRNA-seq) and multiplex smFISH imaging now enable us to address these issues at unprecedented resolution 3 . These technologies illuminate the coordinated communication of cells within their microenvironments that in the heart enable electromechanical connectivity, biophysical interactions, and autocrine/paracrine signaling required for tissue homeostasis but are perturbed in disease.
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