Author: Beigel, John H.; Tebas, Pablo; Elie-Turenne, Marie-Carmelle; Bajwa, Ednan; Bell, Todd E.; Cairns, Charles B.; Shoham, Shmuel; Deville, Jaime G.; Feucht, Eric; Feinberg, Judith; Luke, Thomas; Raviprakash, Kanakatte; Danko, Janine; O’Neil, Dorothy; Metcalf, Julia A.; King, Karen; Burgess, Timothy H.; Aga, Evgenia; Lane, H. Clifford; Hughes, Michael D.; Davey, Richard T.
Title: A Randomized Study of Immune Plasma for the Treatment of Severe Influenza Document date: 2017_5_15
ID: 2g22oqf2_22
Snippet: At baseline, 79 (82%) of participants required oxygen, 56 (58%) were in the ICU, and 41 (43%) were on mechanical ventilation. Adults had a median APACHE II score of 13, reflecting an anticipated 15% mortality, [7] whereas children had a median PRISM III score of 3 reflecting an anticipated 2% mortality. [8] The participants randomized to receive standard care had slightly more severe illness at baseline compared to those randomized to plasma (oxy.....
Document: At baseline, 79 (82%) of participants required oxygen, 56 (58%) were in the ICU, and 41 (43%) were on mechanical ventilation. Adults had a median APACHE II score of 13, reflecting an anticipated 15% mortality, [7] whereas children had a median PRISM III score of 3 reflecting an anticipated 2% mortality. [8] The participants randomized to receive standard care had slightly more severe illness at baseline compared to those randomized to plasma (oxygen requirement in 43 participants (88%) vs. 36 (77%) and mechanical ventilation in 24 participants (49%) vs. 17 (36%)). Thirty five (57%) participants had multi-lobar infiltrates on chest X-ray and was similar in both arms, and 31 (51%) had pleural effusions which were more common in the standard care arm (59% (19) vs 41% (12)). The protocol did not mandate any evaluation of the pleural effusions, though no empyema's were reported. Loss to follow up for completion of the study (Day 28) was higher in the participants that received standard care (22% (N=10) vs. 10% (4)), though follow up through the primary endpoint (or Day 28 if not reaching endpoint, or death) was similar (82% (37) vs. 86% (36)).
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