A review of vaccine development and research for industry animals in Korea

Lee, Nak-Hyung; Lee, Jung-Ah; Park, Seung-Yong; Song, Chang-Seon; Choi, In-Soo; Lee, Joong-Bok

Bacterial vaccines are generally classified into inactivated vaccine, attenuated live vaccine, or antigen component-based vaccine. All are prepared from culture grown on suitable media or other possible means. Inactivated vaccines consist of bacteria of one or more types of bacterial species, serotypes, or well-defined subunit antigens formulated in proper adjuvants. Live vaccines are made of weakened bacteria that are generated through genetic manipulation or attenuation by serially passage of selected microorganisms through artificial media in order to weaken their pathogenicity in the target host. Although many bacterial vaccines have illustrated good outcomes in the control of various types of animal diseases, new vaccines should be developed or improved to control pathogens which are re-emerging in the animal industry and are associated with recent outbreaks. When commercial vaccines are unavailable, autogenous vaccines may be alternatively produced by local veterinary vaccine companies.