Author: Lee, Nak-Hyung; Lee, Jung-Ah; Park, Seung-Yong; Song, Chang-Seon; Choi, In-Soo; Lee, Joong-Bok
Title: A review of vaccine development and research for industry animals in Korea Document date: 2012_7_31
ID: 1c1jd9oz_38
Snippet: Killed vaccines are prepared by culturing bacteria, collecting cells, and inactivating them by suitable means, such as heat treatment or chemicals. This procedure destroys the ability of the pathogens to replicate in the host but keep it intact immunologically. Since such vaccine does not undergo purification of antigen, immunity to vaccine would be induced to virtually all components of bacteria so that some of the antibody would neutralize the .....
Document: Killed vaccines are prepared by culturing bacteria, collecting cells, and inactivating them by suitable means, such as heat treatment or chemicals. This procedure destroys the ability of the pathogens to replicate in the host but keep it intact immunologically. Since such vaccine does not undergo purification of antigen, immunity to vaccine would be induced to virtually all components of bacteria so that some of the antibody would neutralize the pathogen. The best advantage of killed vaccine is safety: there is no opportunity for killed vaccine to revert to a virulent one capable of causing disease due to its composition as completely inactivated bacteria. However, killed vaccine tends to provide a shorter length of protection than live vaccine, and boosters are needed to create a long term immunity. Interestingly, when the B subunit of cholera toxin which lacks toxin activity was expressed, purified, and added to bacteriae protein, the recombinant vaccine had somewhat higher efficacy. A recent study has shown that when using tetanus toxoid as vaccine antigen for subcutaneous immunization, ISS-ODD conjugated cholera toxin B markedly enhanced the antigen specific IgG antibody response and altered the specific pattern of antibody toward Th1-type response.
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