A review of vaccine development and research for industry animals in Korea

Lee, Nak-Hyung; Lee, Jung-Ah; Park, Seung-Yong; Song, Chang-Seon; Choi, In-Soo; Lee, Joong-Bok

For examples, a conjugated vaccine, composed of Vi capsular polysaccharide of S. Typi conjugated with diphtheria toxoid, was generated and inoculated into mice in order to validate its immunogenicity [64] . Immunization of a single dose of the conjugate induced the high titers of anti-V1 IgG, whereas inoculation of the large amount of unconjugated V1 polysaccharide alone showed the suppression of anti-V1 antibody [64] . Capsular polysaccharide of S. pneumoniae conjugated with cholera toxin B subunit evoked mucosal and systemic immune responses after immunization via either peritoneal or intranasal route [65, 66] . been mainly focused on the control of infectious diseases of animals, the current status of development of effective vaccines to reduce foodborne pathogen loads in livestock is highlighted in this section. As an intervention strategy, animal vaccines can also be used for reducing the risk of transmitting zoonotic agents for industry animal to humans through the consumption of meat products. The demand for food products, including meats, is drastically being increased to supply the rapidly growing population worldwide, which results in an increasing population of industry animals. When a large number of industry animals are raised in small regions, there are great chances for infectious diseases, including zoonotic agents, to strike. In particular, some pathogens capable of establishing themselves within industry animals without harmful clinical signs can sometimes become infectious to humans and cause illness. Other types of zoonotic agents can cause clinical signs in both industry animals and humans. Both of them can transmit to humans via food consumption and cause zoonotic illness on humans [10] .